甄永苏，1931年生，籍贯广东开平，微生物药学家，肿瘤药理学家，医药生物技术研究所研究员，博士生导师。1954年本科毕业于中山大学医学院医学专业，同年进入中央卫生研究院从事实验肿瘤学研究。1958年至今在中国医学科学院抗菌素研究所（1987年更名医药生物技术研究所）从事抗肿瘤抗生素研发与相关领域研究工作。1985年晋升研究员。1986为博士生导师。1997年当选中国工程院院士。

抗肿瘤抗生素研究开发及作用机制研究。天然来源的抗肿瘤生化调节药物研究。新型肿瘤靶向抗体偶联药物（ADC）小型化与高效化研究。基于抗体的重组融合蛋白偶联药物的构建与疗效研究。

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1. Du YB#, Wang XF, Liu XJ, Li Y, Miao QF, Jiang M, Sheng WJ*, Zhen YS*. The recombinant defensin/HSA fusion protein that inhibits NF-κb associated with intensive macropinocytosis shows potent efficacy against pancreatic cancer. Biochem Pharmacol. 2022 Jul;201:115057. doi: 10.1016/j.bcp.2022.115057. (IF  6.100)

2. Xu J#, Du Y, Liu XJ, Zhu BY, Zhang SH, Li L, Li Y, Wang XF, Shan CK, Wang RQ, Zhen YS*. Recombinant EGFR/MMP-2 bi-targeted fusion protein markedly binding to non-small-cell lung carcinoma and exerting potent therapeutic efficacy.  Pharmacol Res, 2017,126:66 -76  (IF  4.897)

3. Guo XF#, Zhu XF, Shang Y, Zhang SH, Zhen YS*. A bispecific energized fusion protein containing ligand-based and antibody-based oligopeptides against epidermal growth factor receptor and epidermal growth factor 2 shows potent antitumor activity. Clin Cancer Res, 2010, 16(7):2085-2094.  (IF  7.338)    

4. Zhong GS#, Zhang SH, Li Y, Liu XJ, Gao RJ, Miao QF, Zhen YS*. A tandem scFv-based fusion protein and its enediyne-energized analogue show intensified therapeutic efficacy against lung carcinoma xenograft in athymic mice. Cancer Lett, 2010, 295(1):124-133. (IF 4.864)

5. Jiang B#, Li DD, Zhen YS*. Induction of apoptosis by enediyne antitumor antibiotic C1027 in HL-60 human promyelocytic leukemia cells. Biochem Biophys Res Commun, 1995, 208(1):238-244

6. Xu YJ#, Li DD, Zhen YS*. Mode of action of C-1027, a new macromolecular antitumor antibiotic with highly potent cytotoxicity, on human hepatoma BEL-7402 cells. Cancer Chemother Pharmacol, 1990, 27:41-46

7. Zhen YS#, Min XY, Yu B, Otani T#, Saito H and Yamada T. A new macromolecular antitumor antibiotic, C-1027  Ill. Antitumor activity. J Antibiot, 1989, 42(8):1294-1298

8. Zhen YS#, Lui M and Weber G*. Effect of acivicin and dipyridamole on hepatoma 3924A cells.  Cancer Res, 1983, 43(4):1616-1619

9. 甄永苏#*, 李电东, 林赴田, 李茜, 田佩玉, 薛玉川, 杨小平. 争光霉素A5和争光霉素A2的抗肿瘤作用与毒性研究. 药学学报, 1979, 14(2):83-89

10.甄永苏#*, 赵仪英, 薛玉川, 吕婉瑜, 杨小平. 抗肿瘤药物初筛方法-精原细胞法和噬菌体法的比较研究. 科学通报,1979(8):379-384